Revolutionary drug could be new hope for adrenal cancer patients

TGen Clinical Research Services at Scottsdale Healthcare today announced the start of a clinical trial for a drug designed to combat adrenocortical carcinoma (ACC), a rare but deadly cancer that attacks the adrenal glands.
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Obesity hinders chemotherapy treatment in children with leukemia

Obesity is an important factor contributing to chemotherapy resistance and increasing relapse rates among children with leukemia, according to recent findings published online first in Cancer Research, a journal of the American Association for Cancer Research.
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Expert calls for new cancer research priorities

Cancer research is too focused on new drug development, while not enough money and effort is being devoted to pursuing important advances in knowledge likely to have the biggest impact on combating the disease in the next few decades, a leading research policy expert says, adding that a major shift in research priorities will be crucial to the ability to cope with the coming wave of cancer cases.
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New Protein Partnership That Leads To Pediatric Tumor Regression

Scientists have discovered that the cell receptor TrkA may be involved in the spontaneous regression of some pediatric cancers. Further research towards a better understanding of the mechanism of action might hopefully lead, in the future, to the development of drugs that will be able to induce regression of certain tumors.
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Major Clinical Study Rejects Cancer Safety Fears Of Most Common Heartburn Treatment

Fears about the cancer-causing effects of the second most prescribed group of drugs in the Western world have been put to rest, following the largest ever study into their use.
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Novel 'On-Off Switch' Mechanism Stops Cancer in Its Tracks

(PhysOrg.com) -- A tiny bit of genetic material with no previously known function may hold the key to stopping the spread of cancer, researchers at Yale School of Medicine and Sichuan University in Chengdu, China report in two papers in the September 7-11 issue of Proceedings of the National Academy of Sciences.
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Unraveling How Cells Respond To Low Oxygen

Scientists have elucidated how the stability of the REDD1 protein is regulated. The REDD1 protein is a critical inhibitor of the mTOR signaling pathway, which controls cell growth and proliferation.
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Older Cancer Patients Have More Frailty Than Other Seniors

Older people with a history of cancer are more likely to have disabilities and be frail and vulnerable than older adults who have not had cancer, according to a new study.
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Tumor Mutations Can Predict Chemo Success

Cancer biologists show that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy. The findings should have an immediate impact on cancer treatment, according to researchers. The work could help doctors predict what types of chemotherapy will be effective in a particular tumor, which would help tailor treatments to each patient.
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Key To Strengthening Immune Response To Chronic Infection Found

A team of researchers has identified a protein that could serve as a target for reprogramming immune system cells exhausted by exposure to chronic viral infection into more effective "soldiers" against certain viruses like HIV, hepatitis C and hepatitis B, as well as some cancers, such as melanoma.
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Finding Key To Cancer Drug Gleevec's Limitations

Researchers have learned why imatinib, marketed as Gleevec, helps patients with chronic myeloid leukemia survive longer, but does not keep the disease from returning if treatment ends. The team is now combining imatinib with other drugs in mouse studies to find ways to sensitize resistant leukemia-initiating cells to imatinib and enhance its power.
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Moving To The US Increases Cancer Risk For Hispanics

Results of a new study confirm trends that different Hispanic population groups have higher incidence rates of certain cancers and worse cancer outcomes if they live in the United States, than they do if they live in their homelands.
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Women Often Opt To Surgically Remove Their Breasts, Ovaries To Reduce Cancer Risk

Many women at high risk for breast or ovarian cancer are choosing to undergo surgery as a precautionary measure to decrease their cancer risk, according to a new report.
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Sensitizing Tumor Response To Cancer Therapy

Researchers are working to find natural, biologically active compounds that will sensitize cancerous tumors to therapy without damaging normal tissue.
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Common Trigger In Cancer And Normal Stem Cell Reproduction Found

Researchers have discovered, for the first time, a common molecular pathway that is used by both normal stem cells and cancer stem cells when they reproduce themselves.
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Gene Shut-down May Offer Early Warning Of Chronic Leukemia

A new study shows that certain genes are turned off early in the development of chronic lymphocytic leukemia (CLL), before clinical signs of the disease appear. The study examined cancer cells from CLL patients and from a new strain of mice that develops a very similar disease. The findings suggest that epigenetic alterations might serve as markers for detecting CLL early and for monitoring progression, and that their reversal might delay or prevent progression.
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Delays in UK child brain tumor diagnosis

Significant numbers of children in the UK are suffering from preventable levels of disability, particularly blindness, and premature death because of poor diagnosis of brain tumours.
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Protein Complex Key In Avoiding DNA Repair Mistakes, Cancer

Lymphoma and other cancers may occur when a delicate gene recombination process in antibody-making cells goes awry, according to preliminary studies in mice at the University of Michigan.
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Decoding Leukemia Patient Genome Leads Scientists To Mutations In Other Patients

Scientists have sequenced the complete genome of a patient with acute myeloid leukemia, discovering a suite of genetic changes in the cancer cells. Their research has revealed that one of these mutations also is common in certain brain tumors called gliomas and that another occurred in a second patient with the same type of leukemia. Neither mutation had been previously linked to leukemia.
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Structure Of An Entire HIV Genome Decoded

The structure of an entire HIV genome has been decoded for the first time. The results have widespread implications for understanding the strategies that viruses, like the one that causes AIDS, use to infect humans. The study also opens the door for further research which could accelerate the development of antiviral drugs.
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